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血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)重組蛋白

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4)

ADMP-1; Aggrecanase-1

編號URPK204Hu01
物種Homo sapiens (Human，人) 相同的名稱，不同的物種。
- 所有
- 人
- 小鼠
- 大鼠
- 豚鼠
- 家兔
- 獼猴
- 山羊
- 綿羊
- 馬
- 牛
- 豬
- 雞
- 狗
- 其他物種
- 多物種
- 泛物種
來源原核表達
宿主E.coli
內(nèi)毒素水平<1.0EU/µg(LAL法測定)
亞細(xì)胞定位分泌, 細(xì)胞外基質(zhì)
預(yù)測分子量16.4kDa
實際分子量17kDa(差異分析請參閱說明書)
片段與標(biāo)簽Thr437~Pro575 with N-terminal His Tag
緩沖液成份PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
性狀凍干粉
純度> 95%
等電點7.6
應(yīng)用 Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請參見活性蛋白。
下載英文說明書中文說明書
規(guī)格 10μg50μg 200μg 1mg 5mg
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產(chǎn)品包裝(模擬)
產(chǎn)品包裝(模擬)

SDS-PAGE圖

通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證

序列

用法

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

儲存

避免反復(fù)凍融。2-8°C不超過一個月，-80°C不超過12個月。

穩(wěn)定性

熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲，損失率低于5%。

贈品

聚丙烯酰胺凝膠電泳(PAGE)實驗服務(wù)

增值服務(wù)

去內(nèi)毒素試劑盒
 BCA蛋白定量檢測試劑盒
 蛋白標(biāo)記定制服務(wù)
蛋白分子量MARKER
重組蛋白定制服務(wù)
單克隆抗體定制服務(wù)
多克隆抗體定制服務(wù)
蛋白活性測定實驗服務(wù)
免疫沉淀(IP)實驗服務(wù)
緩沖液
 內(nèi)毒素去除試劑盒Ⅱ
實時熒光定量PCR實驗服務(wù)
棘突蛋白受體結(jié)合結(jié)構(gòu)域
 蛋白G
蛋白 A

相關(guān)產(chǎn)品

編號	適用物種：Homo sapiens (Human，人)	應(yīng)用(僅供研究使用，不用于臨床診斷！)
URPK204Hu01	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)重組蛋白	Positive Control; Immunogen; SDS-PAGE; WB.
UPAK204Hu01	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)多克隆抗體	WB; IHC; ICC; IP.
ULAK204Hu71	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)多克隆抗體(生物素標(biāo)記)	WB; IHC; ICC.
ULAK204Hu81	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)多克隆抗體(異硫氰酸熒光素標(biāo)記)	WB; IHC; ICC; IF.
UMAK204Hu21	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)單克隆抗體	WB; IHC; ICC; IP.
USEK204Hu	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)檢測試劑盒(酶聯(lián)免疫吸附試驗法)	Enzyme-linked immunosorbent assay for Antigen Detection.
ULMK204Hu	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)等多因子檢測試劑盒(流式熒光發(fā)光法)	FLIA Kit for Antigen Detection.
UKSK204Hu01	血小板反應(yīng)蛋白解整合素金屬肽酶4(ADAMTS4)檢測試劑盒DIY材料(酶聯(lián)免疫吸附試驗法)	自己動手制作ELISA試劑盒的主要材料

參考文獻

雜志	參考文獻
Biomedicine & Pharmacotherapy	ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes [ScienceDirect: S0753332209002017]
PLoS ONE	A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches [Plosone: Source]
Anadolu Kardiyol Derg.	A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes. [Pubmed:25592103]
Osteoarthritis and Cartilage	Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium [PubMed: 26521751]
Osteoarthritis and Cartilage	Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized Cavia (Guinea pig )inea pigs [Pubmed:26802547]
Journal of Cellular and Molecular Medicine	VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts [Pubmed:26818776]
Int Wound J.	From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases. [Pubmed:26991748]
The American journal of pathology	Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1β and Fibronectin and Contribution to Cartilage Damage. [pubmed:27449198]
International Wound Journal	From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases [pubmed:26991748]
American Journal of Translational?Research	Diagnostic utility of fluorogenic peptide-conjugated Au nanoparticle probe corroborated by rabbit model of mild cartilage injury and panel of osteoarthritic?… [Pubmed: 30210670]
Journal of Clinical Medicine	The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma?… [Pubmed:35407621]

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