β-位淀粉樣前體蛋白裂解酶1(bACE1)重組蛋白
Recombinant Beta-Site APP Cleaving Enzyme 1 (bACE1)
ASP2; Beta Secretase; Memapsin 2; Aspartyl protease 2; Beta-site amyloid precursor protein cleaving enzyme 1; Membrane-associated aspartic protease 2
- 編號(hào)URPA718Hu01
- 物種Homo sapiens (Human，人) 相同的名稱，不同的物種。
- 來源原核表達(dá)
- 宿主E.coli
- 內(nèi)毒素水平<1.0EU/µg(LAL法測(cè)定)
- 亞細(xì)胞定位細(xì)胞膜, 內(nèi)質(zhì)網(wǎng)腔
- 預(yù)測(cè)分子量59.1kDa
- 實(shí)際分子量59kDa(差異分析請(qǐng)參閱說明書)
- 片段與標(biāo)簽Phe170~Thr428 with N-terminal His and GST Tag
- 緩沖液成份20mM Tris, 150mM NaCl緩沖液（pH8.0, 含有1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose和Proclin300）
- 性狀凍干粉
- 純度> 90%
- 等電點(diǎn)5.2
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應(yīng)用
Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請(qǐng)參見活性蛋白。 - 下載 英文說明書 中文說明書
- 規(guī)格 10μg50μg 200μg 1mg 5mg
- 價(jià)格 ¥ 360 ¥ 900 ¥ 1800 ¥ 5400 ¥ 13500
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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Figure. Gene Sequencing (Extract)
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SDS-PAGE圖
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通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
序列
用法
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
儲(chǔ)存
避免反復(fù)凍融。2-8°C不超過一個(gè)月，-80°C不超過12個(gè)月。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗(yàn)決定，具體方法如下：在37°C孵育48小時(shí)，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲(chǔ)，損失率低于5%。
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| 編號(hào) | 適用物種：Homo sapiens (Human，人) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| URPA718Hu01 | β-位淀粉樣前體蛋白裂解酶1(bACE1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UPAA718Hu01 | β-位淀粉樣前體蛋白裂解酶1(bACE1)多克隆抗體 | IHC |
| UMAA718Hu23 | β-位淀粉樣前體蛋白裂解酶1(bACE1)單克隆抗體 | IHC |
| UMAA718Hu24 | β-位淀粉樣前體蛋白裂解酶1(bACE1)單克隆抗體 | IHC |
| UMAA718Hu25 | β-位淀粉樣前體蛋白裂解酶1(bACE1)單克隆抗體 | IHC |
| UMAA718Hu22 | β-位淀粉樣前體蛋白裂解酶1(bACE1)單克隆抗體 | WB |
| UMAA718Hu21 | β-位淀粉樣前體蛋白裂解酶1(bACE1)單克隆抗體 | IHC |
| USEA718Hu | β-位淀粉樣前體蛋白裂解酶1(bACE1)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| ULMA718Hu | β-位淀粉樣前體蛋白裂解酶1(bACE1)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
| UKSA718Hu01 | β-位淀粉樣前體蛋白裂解酶1(bACE1)檢測(cè)試劑盒DIY材料(酶聯(lián)免疫吸附試驗(yàn)法) | Main materials for "Do It(ELISA Kit) Yourself" |
參考文獻(xiàn)
| 雜志 | 參考文獻(xiàn) |
| Food & Function | Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer’s disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice [pubmed:29292421] |
| Journal of Functional Foods | EPA enriched ethanolamine plasmalogens significantly improve cognition of Alzheimer's disease mouse model by suppressing β-amyloid generation [10.1016/j.jff.2017.12.016] |
| Journal?of?Nutritional?Biochemistry | Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet [Pubmed:29986309] |
| Neurotoxicology | Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice [Pubmed: 32522471] |
| Food Chem Toxicol | Effects of Alcohol Intake on Cognitive Function and |?-amyloid Protein in APP/PS1 Transgenic Mice [33737111] |
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